منابع مشابه
ER membrane–bending proteins are necessary for de novo nuclear pore formation
Nucleocytoplasmic transport occurs exclusively through nuclear pore complexes (NPCs) embedded in pores formed by inner and outer nuclear membrane fusion. The mechanism for de novo pore and NPC biogenesis remains unclear. Reticulons (RTNs) and Yop1/DP1 are conserved membrane protein families required to form and maintain the tubular endoplasmic reticulum (ER) and the postmitotic nuclear envelope...
متن کاملNuclear Envelope: Membrane Bending for Pore Formation?
Membrane-shaping proteins known as reticulons help to sculpt the endoplasmic reticulum; recent findings indicate that they also play a role in the formation of nuclear-pore-complex-associated pores in the nuclear envelope.
متن کاملA membrane bending model of outer hair cell electromotility.
We propose a new mechanism for outer hair cell electromotility based on electrically induced localized changes in the curvature of the plasma membrane (flexoelectricity). Electromechanical coupling in the cell's lateral wall is modeled in terms of linear constitutive equations for a flexoelectric membrane and then extended to nonlinear coupling based on the Langevin function. The Langevin funct...
متن کاملMIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.
Proper morphogenesis of neuronal dendritic spines is essential for the formation of functional synaptic networks. However, it is not known how spines are initiated. Here, we identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protru...
متن کاملEndophilin functions as a membrane-bending molecule provided by exocytosis
Two models have been proposed for Endophilin function in synaptic vesicle (SV) endocytosis. The scaffolding model proposes that Endophilin’s SH3 domain recruits essential endocytic proteins whereas the membrane-bending model proposes that the BAR domain induces positively curved membranes. We show that mutations disrupting the scaffolding function do not impair endocytosis, while those disrupti...
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ژورنال
عنوان ژورنال: Critical Reviews in Biochemistry and Molecular Biology
سال: 2009
ISSN: 1040-9238,1549-7798
DOI: 10.1080/10409230903183472